EBV-lytic activation reflects a higher level of disease activity with gene expression and is related to the development of EBV lymphomas or EBV-related cancer. There is no doubt that IBD disorders are serious and need intervention, but at what price? Inflammatory bowel disorders with EBV are also found in children, not just adults.
Of the children in this study, 64 percent had a higher EBV viral load associated with the immunosuppressant drug. Azathioprine is a powerful drug. Based on these recent studies, patients undergoing aggressive anti-TNF therapy, azathioprine and steroid drugs absolutely must be tested for EBV status and activity. Unfortunately, a common belief is that EBV is benign and dormant in most people.
This misinformation may lead to a high-risk, deadly situation if the medical provider is unaware of this research or dismisses the severity of this common virus. Appendicitis and Epstein Barr Virus In addition to IBD and peptic ulcer disease, very limited research shows that some acute appendicitis problems are due to viral infection or reactivation. It is commonly recognized that bacterial infections are the cause of appendicitis; now add these other factors to the gut microbiome and gut virome gut viral load.
Individuals struggling with inflamed digestive tracts to the point of ulcers and inflammatory bowel diseases must work with their physicians to identify if EBV is a clear and present danger for them.
Several studies cited the mandatory need for this type of evaluation to avoid life-threatening problems. Those who choose to follow the path of steroids, azathioprine, and anti-TNF therapy drugs absolutely must be aware of the EBV risk. Natural support offers safe, supportive measures to down regulate and inhibit EBV activity without the deadly consequences seen with other therapies.
If you need to use the medical treatment, strongly consider the resources listed above to complement and nourish healthy defenses. This research shows another face of the sleeping giant virus that has been falsely assumed as benign.
Search thousands of health news articles! Search News Submit Search News. See all. Primary CMV infection is followed by either chronic infection or viral latency from which the virus may be reactivated. CMV infection of the gastrointestinal tract occurs mainly in immunocompromised individuals, including those with inflammatory bowel disease IBD and those who have received transplants. We herein report, to our knowledge, the first case of an immunodeficient patient with severe hemorrhagic colitis associated with the reactivation of both EBV and CMV, and whose endoscopic findings mimicked IBD.
A year-old man was diagnosed with severe aplastic anemia SAA , showing pancytopenia and severe bone marrow hypocellularity; therefore, he was treated with antithymocyte globulin ATG and cyclosporine CSP. Blood tests revealed the following results: hemoglobin level 4.
The patient's C-reactive protein level was 4. Stool cultures showed no bacterial infection. Colonoscopy revealed severe edema and multiple superficial ulcers fig. The patient was diagnosed with severe colitis resembling IBD.
Histopathological analysis of the biopsy specimen revealed non-specific inflammation fig. We initially thought the colitis to be associated with CMV infection because of the endoscopic features and positive result for serum CMV antigen in spite of negative results obtained using immunohistochemical analysis.
Therefore, the patient was treated with ganciclovir for 2 weeks; however, his symptoms did not resolve. As the colitis was similar to IBD, the patient received secondary steroid therapy.
However, his symptoms persisted for the next 2 weeks. Therefore, assuming a potential misdiagnosis, a second colonoscopy was performed, which showed multiple deep ulcerations fig. Immunohistochemical analysis of colonic biopsy samples revealed CMV-positive cells fig. Retrospective analysis of the first colonic biopsy samples also showed EBERpositive cells. After cessation of CSP and treatment with gamma globulin and ganciclovir, his symptoms resolved.
Follow-up colonoscopy after 3 months showed multiple ulcer scars. Endoscopic images. Colonoscopy performed at admission revealed multiple erosions and edema a and round ulcerations b. Histological images of the colonic mucosa. Interestingly, 6 months after the first remission, the patient had a recurrence of severe bloody diarrhea after an increase in the CSP dose.
After a second round of treatment with gamma globulin and ganciclovir and cessation of CSP, his symptoms resolved. The patient has had no abdominal symptoms for 1. EBV primary infected B cells, CMV was designed to enter monocytes besides lymphocytes, whereas both of them also infected epithelial cells [ 4 ].
However, reactivation of both these viruses has not been reported, and the clinical features are not well known. Interestingly, the patient had two colitis attacks with identical clinical symptoms and EBV results. Forgot your log in details? Register a new account? Forgot your user name or password? Search for this keyword. Advanced search. Log in via Institution. Email alerts. Article Text.
Article menu. Reminder of important clinical lesson. EBV colitis with ulcerative colitis: a double whammy.
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